Review of the biological aspects in the periodontal ligament and alveolar bone associated with compression

  • Andrea Castilho Soares de Azevedo Dentist – post graduation UNIFESP
  • Lydia M. Ferreira Titular Discipline Plastic Surgery UNIFESP
  • Antonio Carlos Aloise Affiliate of the Discipline of Plastic Surgery at UNIFESP

Abstract

Background: Tissue remodeling requires protein degradation through a process directly dependent on metalloproteinases — enzymes capable of degrading the majority of proteins in this system. This process is regulated by some enzyme inhibitors, and balance between enzyme and inhibitor activity is fundamental to tissue integrity and health. Bone resorption and formation, and the molecules involved in these processes, raise questions on possible differences in tissue behavior in the system. Histological studies of tissues surrounding teeth that have been subjected to such forces show the presence of tension (associated with bone formation) and compression, which induce bone resorption. The duration of load application is an important parameterin osteoclastogenesis. The present study aimed to analyze the biological aspects associated with in vitro compression of the PL and alveolar bone. To this end, we reviewed articles describing the biological events that occur in the PL and alveolar bone during load application on this system and the possible influence of culture medium on the expression of molecules involved in response to such an event.


Methods: This literature review included articles published between March 2008 and January 2018 describing in vitro laboratory tests and data on load application and its associated biological events in the human PL and alveolar bone, including studies on molecular-expression events and pathways involved in the process.


Conclusions: Intermittent compressive forces stimulate bone resorption in orthodontic treatment, while cyclical forces induce cellular apoptosis at lighter loads than do compressive forces. Both 2D and 3D cell-culture systems seem to reproduce the physiology of evaluated tissues and are reliable analytical models for research purposes.

References

Alves LB, Mariguela VC, Grisi MF, Souza SL, Novaes Junior AB, Taba Junior M, Oliveira PT, Palioto DB. Expression of osteoblastic phenotype in periodontal ligament fibroblasts cultured in three-dimensional collagen gel.J Appl Oral Sci. 2015 Mar-Apr;23(2):206-14.

Bloemem V, Schoenmaker T, De Vries T, Everts V. Direct cell-cell contact between periodontal ligament fibroblasts and osteoclast precursors. J Cell Physiol. 2009; 222:565-73.

Cardaropoli D, Tamagnone L, Roffredo A, Gaveglio L. Treatment of gingival recession defects using coronally advanced flap with a porcine collagen matrix compared to coronally advanced flap with connective tissue graft: a randomized controlled clinical trial. J Periodontol. 2012 Mar;83(3):321-8

Diercke K., Sen S., Kohl A., Lux C.J. and Erber R.Compression-depend Up-regulation of Ephrin-A2 in PDL Fibroblasts attenuates osteogenesis.
J Dent Res.2011; 90(9): 1108-1115.

Feng L, Zhang Y, Kou X, Yang R, Liu D, Wang X, Song Y, Cao H, He D, Gan Y, Zhou Y. Cadherin-11 modulates cell morphology and collagen synthesis in periodontal ligament cells under mechanical stress. Angle Orthod. 2016; Sep 30.

Hacopian N, Hosseinzadeh-Nik T, Ghahremani MH, Rahimi HR, Ostad SN. Effects of continuous and interrupted forces on gene transcription in periodontal ligament cells in vitro. Acta Medica Iranica. 2011; 10: 643-9.

Jacobs C., Walter C., Ziebart T., Dirks I. , Schramm S. , Grimm S., Krieger E., Wehrbein H. Mechanical loading influences the effects of bisphosphonates on human periodontal ligament fibroblastos.Clin Oral Invest .2015;19:699-708.

Kearns AE, Khosla S, Kostenuik PJ .Receptor activator of nuclear factor kappaB ligand and osteoprotegerin regulation of bone remodeling in health and disease. Endocr Rev. 2008; 29:155–192

Kook SH, Son YO, Hwang JM, Kim FM, Lee CB, Jeon YM, Kim JG, Lee JC. Mechanical force inhibits osteoclastogenic potential of human periodontal ligament fibroblasts through OPG production and ERK-mediated signaling. . J Cell Biochem. 2009; 106:101-1019.

L. Nettelhoff1 , S. Grimm , C. Jacobs , C. Walter . A. M. P. , J. Goldschmitt and H. Wehrbein Influence of mechanical compression on human periodontal ligament fibroblasts and osteoblasts. Clin Oral Invest. 2016 ;20:621–629

Li Y, Zheng W, Liu JS, Wang J, Yang P, Li ML, Zhao ZH Expression of osteoclastogenesis inducers in a tissue model of peri- odontal ligament under compression. J Dent Res. 2011; 90:115–120 


Liu J, Bian Z, Kuijpers-Jagtman AM, et al. Skin and oral mucosa equivalents: Construction and performance. Orthod Craniofac Res. 2010;13:11–20.

Lossdorfer S, Gotz W and Jager A. Induced changes in RANKL and OPG expression by human PDL cells modify osteoclast biology in a co-culture model with RAW 264.7 cells. Clin Oral Investig. 2011;15:941–952

Mitsuhashi M., Yamaguchi M.,Kojima T. , Nakajima R., Kasai K. Effects of HSP70 on the compression force-induced TNF and RANKL expression. In human periodontal ligament cells.Inflamm. Res. 2011;60:187-194.

Nokhbehsaim M.,Deschner B., Winter J., Bourauel C.,Jager A. , Jepsen S.,Deschner J. Anti-inflammatory effects of EMD in the presence of biomechanical loading and interleukin-1b in vitro.Clin Oral Invest. 2012; 16:275-283.

Piero Römer & Josef Köstler & Vasiliki Koretsi & Peter Proff. Endotoxins potentiate COX-2 and RANKL expression in compressed PDL cells Clin Oral Invest .2013 ; 17:2041–2048.

Sheikh Z, Qureshi J, Alshahrani AM, Nassar H, Ikeda Y, Glogauer M, Ganss B. Collagen based barrier membranes for periodontal guided bone regeneration applications. Odontology. 2016 ;Sep 9.

Wescott DC, Pinkerton MN, Gaffey BJ, Beggs KT, Milne TJ, Meikle MC .Osteogenic gene expression by human periodontal ligament cells under cyclic tension. J Dent Res.2007; 86:1212.

Yasuda H, Shima N, Nakagawa N, Yamaguchi K, Kinosaki M, Mochizuki S, Tomoyasu A, Yano K, Goto M, Murakami A, Tsuda E, Morinaga T, Higashio K, Udagawa N, Takahashi N, Suda T. Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis inhibitory factor and is identical to TRANCE/RANKL. Proc Natl Acad Sci U S A.2009 ; 95:3597–3602 .
Published
2020-03-15
How to Cite
AZEVEDO, Andrea Castilho Soares de; FERREIRA, Lydia M.; ALOISE, Antonio Carlos. Review of the biological aspects in the periodontal ligament and alveolar bone associated with compression. International Archives of Medicine, [S.l.], v. 13, mar. 2020. ISSN 1755-7682. Available at: <http://imedicalpublisher.com/ojs/index.php/iam/article/view/2922>. Date accessed: 19 jan. 2021. doi: https://doi.org/10.3823/2625.
Section
Dental Medicine