Use of Antioxidant Substances in Intestinal Anastomosis in Rats
Abstract
Introduction: Intestinal anastomosis consist of surgical procedures which there is an anastomotic line between two intestinal segments in order to reconstruct or divert the digestive transit. However, several complications may result from this surgical procedure.
Objective: Present, describe and discuss the findings of the literature regarding substances capable of reducing injury and possible complications of intestinal anastomoses.
Method: The data were collected by literature review using the descriptors: "intestinal anastomoses", "antioxidants"; and as basis articles published in the published Scientific Electronic Library (Scielo), Lilacs, MedLine and Pubmed databases. Inclusion criteria were original and review articles published in full in the online form in the Portuguese, Spanish and English languages, using the descriptors mentioned above in the respective languages.
Results: Scientific articles were collected, in which 38 papers were included in the inclusion criteria.
Conclusions: The major parts of substances described in the present study demonstrated be statistically relevant results and the capacity to optimize the anastomotic healing.
References
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2- Yuan, Y., Wang, K.-N., & Chen, L.-Q. (2014). Esophageal anastomosis. Diseases of the Esophagus, 28(2), 127–137. doi:10.1111/dote.12171
3- De Nardi, P., Panzeri, F., & Staudacher, C. (2008). Prospective trial evaluating new circular and linear stapler devices for gastrointestinal anastomosis: preliminary data. Techniques in Coloproctology, 12(1), 69–72.doi:10.1007/s10151-008-0401-2 .
4- Campos M.T.G., Leme F.O.P.(2018) Estresse oxidativo: fisiopatogenia e diganóstico laboratorial. Pubvet, v.12, n.1, a10, p.1-8, Jan.
5- Zou Z., Xi, W., Hu, Y., Nie, C., & Zhou, Z. (2016). Antioxidant activity of Citrus fruits. Food Chemistry, 196, 885–896.doi:10.1016/j.foodchem.2015.09.072
6- Reiter, R. J., Mayo, J. C., Tan, D.-X., Sainz, R. M., Alatorre-Jimenez, M., & Qin, L. (2016). Melatonin as an antioxidant: under promises but over delivers. Journal of Pineal Research, 61(3), 253–278.doi:10.1111/jpi.12360
7- Martins F. J., Caneschi C. A., Vieira J. L. F., Barbosa W., Raposo N. R. B. (2016). Antioxidant activity and potential photoprotective from amazon native flora extracts. Journal of Photochemistry and Photobiology B: Biology, 161, 34–39.doi:10.1016/j.jphotobiol.2016.05.012
8- Chadi S. A., Fingerhut A., Berho M., DeMeester S. R., Fleshman J. W., Hyman N. H., Wexner S. D. (2016). Emerging Trends in the Etiology, Prevention, and Treatment of Gastrointestinal Anastomotic Leakage. Journal of Gastrointestinal Surgery, 20(12), 2035–2051.doi:10.1007/s11605-016-3255-3
9- Rocha, J.R. (2011). Estomas intestinais (ileostomias Estomas intestinais (ileostomias e colostomias) e anastomoses e colostomias) e anastomoses intestinais intestinais. Medicina (Ribeirão Preto) 2011;44(1): 51-6
10- Kano M, Hanari N, Gunji H, Hayashi H, Matsubara H.( 2017). Is "functional end-to-end anastomosis" really functional? A review of the literature on stapled anastomosis using linear staplers. Surg today.
11- Junior C.S,; De Souza C., Gomes C.A., Soares F.P.T.P. (2010). Fatores intervenientes e métodos de avaliação das anastomoses gastrointestinais. Rev. Méd., Minas Gerais, v. 20, n. 3, 2010.
12- Blumetti J, Abcarian H. (2015). Management of low colorectal anastomotic leak: preserving the anastomosis. World J Gastrointest surg. 2015.
13- Corsi P.R., Kanashiro E., Schiola A.; Cretella C.M., Gagliardi D.(2000).Tratamento cirúrgico das complicações da anastomose esôfago-visceral cervical. Rev. Col. Bras. Cir., v. 27, n. 5, p.293-297, set./out. 2000.
14- Paixão R.L. (2001) Experimentação animal: razões e emoções para uma ética. Rio de Janeiro: Fundação Oswaldo Cruz, Escola Nacional de Saúde Pública;
15- Feng, Chung Wu, et al. (2003). Estudos biomecânicos da ação de aderências sobre anastomose cólica: trabalho experimental em ratos. Acta Cirúrgica Brasileira, 2003.
16- Hendriks, T., Mastboom, W. J. B. (1990). Healing of experimental intestinal anastomoses. Diseases of the Colon & Rectum, 33(10), 891–901. doi:10.1007/bf02051930
17- Hendriks, T., Mastboom, W. J. B. (1990). Healing of experimental intestinal anastomoses. Diseases of the Colon & Rectum, 33(10), 891–901. doi:10.1007/bf02051930
18- Durães L.C., Durães E.F.R., Lobato L.F.C., Oliveira P.G, Sousa J.B. (2013) Correlation between bursting pressure and breaking strength in colonic anastomosis. Acta Cir. Bras. [Internet]. Available from: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S010286502013000600008&lng=en. http://dx.doi.org/10.1590/S0102-86502013000600008.
19- Brito M.V.H., Koh I. H. J., Lamarão L. G., Damous S. H. B. (2001) Efeito do choque hipovolêmico na anastomose do intestino delgado de ratos. Arq Gastroenterol V. 38, n. 2, abri/jun.
20- Chaturvedi, A. A., Yauw, S. T. K., Lomme, R. M. L. M., Hendriks, T., & van Goor, H. (2017). Safety and Efficacy of Alginate Adhesion Barrier Gel in Compromised Intestinal Anastomosis. Surgical Infections, 18(6), 670–675.doi:10.1089/sur.2016.086
21- Chaturvedi, A. A., Yauw, S. T. K., Lomme, R. M. L. M., Hendriks, T., & van Goor, H. (2017). Safety and Efficacy of Alginate Adhesion Barrier Gel in Compromised Intestinal Anastomosis. Surgical Infections, 18(6), 670–675.doi:10.1089/sur.2016.086
22- Azevedo J. L. M., Silva C. E. D., Azevedo O. C., Simões M. J., Kobayashi L. A., Kozonara M. (2004) Técnicas de sutura do tubo digestivo em plano único total em jejuno de cães: pontos de gambee com nós atados na serosa versus pontos totais atados no lumen, sobre a mucosa. Acta cirúrgica brasileira, vol. 19 (2).
23- Petroianu A., Alberti L. R., Souza S., Martins S. G. Efeito do ácido ascórbico e da hidrocortisona na cicatrização anastomótica intestinal. (2009) Rev. Col. Bras. Cir. [Internet]. 2009 Available from: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S010069912009000600009&lng=en. http://dx.doi.org/10.1590/S0100-69912009000600009.
24- Petroianu A., Souza S. D., Martins S. G., Alberti L. R. (2001) Influência do ácido ascórbico em anastomoses e alças jejunais íntegras de rato. Arq. Gastroenterol. [Internet]. 2001 Available from: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S000428032001000100009&lng=en. http://dx.doi.org/10.1590/S0004-28032001000100009.
25- Şekeroğlu Z. A., Aydın B., Şekeroğlu, V. (2017). Argan oil reduces oxidative stress, genetic damage and emperipolesis in rats treated with acrylamide. Biomedicine & Pharmacotherapy, 94, 873–879.doi:10.1016/j.biopha.2017.08.034
26- Barlas A.M, Kuru S, Kismet K, Cavusoglu T, Bag Y M, Senes M, et al. (2018) Rectal application of argan oil improves healing of colorectal anastomosis in rats. Acta Cir. Bras. [Internet]. Available from: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502018000700565&lng=en. http://dx.doi.org/10.1590/s0102-865020180070000002.
27- Ozkan N.; Ersoy O. F.; Ozsoy Z.; Çakir, E. (2018) Melatonin exhibits supportive effects on oxidante and anastomotic healing during intestinal ischemia/reperfusion injury. Ulus Trauma Acil Cerrahi Derg, vol.24, No1
28- Ercan U., Kiraz A., Çikman Ö., Türkön H., Kilinç N., Otkun M. T., Karaayvaz, M. (2015). The Effect of Systemic Carnitine Administration on Colon Anastomosis Healing in an Experimental Sepsis Model. Journal of Investigative Surgery, 28(6), 334–340.doi:10.3109/08941939.2015.1029652
29- Oliveira J. C. C., Oliveira C. H., Oliveira H. E., Pereira A., Maraschin M., d'Acâmpora A. J. Effects of perioperative hypothermia and reactive oxygen species in the healing of colonic anastomosis in rats. (2014) Acta Cir. Bras. [Internet]. 2014 Nov [cited 2019 May 15] ; 29( 11 ): 742-747. Available from: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S010286502014001100742&lng=en. http://dx.doi.org/10.1590/S0102-86502014001800008
30- Wheeless C. R., Zanagnolo V., Bowers D., Brenner M. J., Lilley R. (1998). The Effect of Growth Hormone on the Bursting Strength of Ileal Anastomotic Segments in Radiation-Injured Rat Bowel. Gynecologic Oncology, 70(1), 121–122. doi:10.1006/gyno.1998.5045
31- Karahasanoglu, Altinli, Hamzaoglu, Paksoy, Yesildere, Alemdaroglu. (1998). Effect of growth hormone treatment on the healing of left colonic anastomoses in protein-malnourished rats. British Journal of Surgery, 85(7), 931–933.doi:10.1046/j.1365-2168.1998.00696.x
32- Ceran C., Aksoy R. T., Gülbahar Ö., Öztürk F. The effects of ghrelin on colonic anastomosis healing in rats. (2013) Clinics [Internet]. Available from: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S180759322013000200019&lng=en. http://dx.doi.org/10.6061/CLINICS/2013(02)OA19.
33- Teke Z., Bostanci E. B., Yenisey C., Kelten E. C., Sacar M., Simsek N. G., Akoglu, M. (2012). Caffeic Acid Phenethyl Ester Prevents Detrimental Effects of Remote Ischemia-Reperfusion Injury on Healing of Colonic Anastomoses. Journal of Investigative Surgery, 26(1), 16–29.doi:10.3109/08941939.2012.687434
34- Turku O, et al. The effect of erythropoietin on anastomotic healing of irradiated rats. (2012) J invest Surg.
35- Pavlidis, E. T., Ballas, K. D., Symeonidis, N. G., Psarras, K., Koliakos, G., Kouzi-Koliakos, K. Sakantamis, A. K. (2010). The effect of bevacizumab on colon anastomotic healing in rats. International Journal of Colorectal Disease, 25(12), 1465–1473.doi:10.1007/s00384-010-1039-x
36- Yalçın, A. S. (2006) Emerging therapeutic potential of whey proteins and peptides. Curr. Pharm. Des. 12, 1637–1643.
37- Velioglu Ogunç, et al. (2008) Dietary whey supplementation in experimental models of wound healing. International journal of vitamin and nutrition research, 78(2), 70-73.
38- Temiz, M., Aslan, A., Canbolant, E., Hakverdi, S., Polat, G., Uzun, S., Gonenci, R. (2008). Effect of propolis on healing in experimental colon anastomosis in rats. Advances in Therapy, 25(2), 159–167.doi:10.1007/s12325-008-0013-2
2- Yuan, Y., Wang, K.-N., & Chen, L.-Q. (2014). Esophageal anastomosis. Diseases of the Esophagus, 28(2), 127–137. doi:10.1111/dote.12171
3- De Nardi, P., Panzeri, F., & Staudacher, C. (2008). Prospective trial evaluating new circular and linear stapler devices for gastrointestinal anastomosis: preliminary data. Techniques in Coloproctology, 12(1), 69–72.doi:10.1007/s10151-008-0401-2 .
4- Campos M.T.G., Leme F.O.P.(2018) Estresse oxidativo: fisiopatogenia e diganóstico laboratorial. Pubvet, v.12, n.1, a10, p.1-8, Jan.
5- Zou Z., Xi, W., Hu, Y., Nie, C., & Zhou, Z. (2016). Antioxidant activity of Citrus fruits. Food Chemistry, 196, 885–896.doi:10.1016/j.foodchem.2015.09.072
6- Reiter, R. J., Mayo, J. C., Tan, D.-X., Sainz, R. M., Alatorre-Jimenez, M., & Qin, L. (2016). Melatonin as an antioxidant: under promises but over delivers. Journal of Pineal Research, 61(3), 253–278.doi:10.1111/jpi.12360
7- Martins F. J., Caneschi C. A., Vieira J. L. F., Barbosa W., Raposo N. R. B. (2016). Antioxidant activity and potential photoprotective from amazon native flora extracts. Journal of Photochemistry and Photobiology B: Biology, 161, 34–39.doi:10.1016/j.jphotobiol.2016.05.012
8- Chadi S. A., Fingerhut A., Berho M., DeMeester S. R., Fleshman J. W., Hyman N. H., Wexner S. D. (2016). Emerging Trends in the Etiology, Prevention, and Treatment of Gastrointestinal Anastomotic Leakage. Journal of Gastrointestinal Surgery, 20(12), 2035–2051.doi:10.1007/s11605-016-3255-3
9- Rocha, J.R. (2011). Estomas intestinais (ileostomias Estomas intestinais (ileostomias e colostomias) e anastomoses e colostomias) e anastomoses intestinais intestinais. Medicina (Ribeirão Preto) 2011;44(1): 51-6
10- Kano M, Hanari N, Gunji H, Hayashi H, Matsubara H.( 2017). Is "functional end-to-end anastomosis" really functional? A review of the literature on stapled anastomosis using linear staplers. Surg today.
11- Junior C.S,; De Souza C., Gomes C.A., Soares F.P.T.P. (2010). Fatores intervenientes e métodos de avaliação das anastomoses gastrointestinais. Rev. Méd., Minas Gerais, v. 20, n. 3, 2010.
12- Blumetti J, Abcarian H. (2015). Management of low colorectal anastomotic leak: preserving the anastomosis. World J Gastrointest surg. 2015.
13- Corsi P.R., Kanashiro E., Schiola A.; Cretella C.M., Gagliardi D.(2000).Tratamento cirúrgico das complicações da anastomose esôfago-visceral cervical. Rev. Col. Bras. Cir., v. 27, n. 5, p.293-297, set./out. 2000.
14- Paixão R.L. (2001) Experimentação animal: razões e emoções para uma ética. Rio de Janeiro: Fundação Oswaldo Cruz, Escola Nacional de Saúde Pública;
15- Feng, Chung Wu, et al. (2003). Estudos biomecânicos da ação de aderências sobre anastomose cólica: trabalho experimental em ratos. Acta Cirúrgica Brasileira, 2003.
16- Hendriks, T., Mastboom, W. J. B. (1990). Healing of experimental intestinal anastomoses. Diseases of the Colon & Rectum, 33(10), 891–901. doi:10.1007/bf02051930
17- Hendriks, T., Mastboom, W. J. B. (1990). Healing of experimental intestinal anastomoses. Diseases of the Colon & Rectum, 33(10), 891–901. doi:10.1007/bf02051930
18- Durães L.C., Durães E.F.R., Lobato L.F.C., Oliveira P.G, Sousa J.B. (2013) Correlation between bursting pressure and breaking strength in colonic anastomosis. Acta Cir. Bras. [Internet]. Available from: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S010286502013000600008&lng=en. http://dx.doi.org/10.1590/S0102-86502013000600008.
19- Brito M.V.H., Koh I. H. J., Lamarão L. G., Damous S. H. B. (2001) Efeito do choque hipovolêmico na anastomose do intestino delgado de ratos. Arq Gastroenterol V. 38, n. 2, abri/jun.
20- Chaturvedi, A. A., Yauw, S. T. K., Lomme, R. M. L. M., Hendriks, T., & van Goor, H. (2017). Safety and Efficacy of Alginate Adhesion Barrier Gel in Compromised Intestinal Anastomosis. Surgical Infections, 18(6), 670–675.doi:10.1089/sur.2016.086
21- Chaturvedi, A. A., Yauw, S. T. K., Lomme, R. M. L. M., Hendriks, T., & van Goor, H. (2017). Safety and Efficacy of Alginate Adhesion Barrier Gel in Compromised Intestinal Anastomosis. Surgical Infections, 18(6), 670–675.doi:10.1089/sur.2016.086
22- Azevedo J. L. M., Silva C. E. D., Azevedo O. C., Simões M. J., Kobayashi L. A., Kozonara M. (2004) Técnicas de sutura do tubo digestivo em plano único total em jejuno de cães: pontos de gambee com nós atados na serosa versus pontos totais atados no lumen, sobre a mucosa. Acta cirúrgica brasileira, vol. 19 (2).
23- Petroianu A., Alberti L. R., Souza S., Martins S. G. Efeito do ácido ascórbico e da hidrocortisona na cicatrização anastomótica intestinal. (2009) Rev. Col. Bras. Cir. [Internet]. 2009 Available from: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S010069912009000600009&lng=en. http://dx.doi.org/10.1590/S0100-69912009000600009.
24- Petroianu A., Souza S. D., Martins S. G., Alberti L. R. (2001) Influência do ácido ascórbico em anastomoses e alças jejunais íntegras de rato. Arq. Gastroenterol. [Internet]. 2001 Available from: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S000428032001000100009&lng=en. http://dx.doi.org/10.1590/S0004-28032001000100009.
25- Şekeroğlu Z. A., Aydın B., Şekeroğlu, V. (2017). Argan oil reduces oxidative stress, genetic damage and emperipolesis in rats treated with acrylamide. Biomedicine & Pharmacotherapy, 94, 873–879.doi:10.1016/j.biopha.2017.08.034
26- Barlas A.M, Kuru S, Kismet K, Cavusoglu T, Bag Y M, Senes M, et al. (2018) Rectal application of argan oil improves healing of colorectal anastomosis in rats. Acta Cir. Bras. [Internet]. Available from: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502018000700565&lng=en. http://dx.doi.org/10.1590/s0102-865020180070000002.
27- Ozkan N.; Ersoy O. F.; Ozsoy Z.; Çakir, E. (2018) Melatonin exhibits supportive effects on oxidante and anastomotic healing during intestinal ischemia/reperfusion injury. Ulus Trauma Acil Cerrahi Derg, vol.24, No1
28- Ercan U., Kiraz A., Çikman Ö., Türkön H., Kilinç N., Otkun M. T., Karaayvaz, M. (2015). The Effect of Systemic Carnitine Administration on Colon Anastomosis Healing in an Experimental Sepsis Model. Journal of Investigative Surgery, 28(6), 334–340.doi:10.3109/08941939.2015.1029652
29- Oliveira J. C. C., Oliveira C. H., Oliveira H. E., Pereira A., Maraschin M., d'Acâmpora A. J. Effects of perioperative hypothermia and reactive oxygen species in the healing of colonic anastomosis in rats. (2014) Acta Cir. Bras. [Internet]. 2014 Nov [cited 2019 May 15] ; 29( 11 ): 742-747. Available from: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S010286502014001100742&lng=en. http://dx.doi.org/10.1590/S0102-86502014001800008
30- Wheeless C. R., Zanagnolo V., Bowers D., Brenner M. J., Lilley R. (1998). The Effect of Growth Hormone on the Bursting Strength of Ileal Anastomotic Segments in Radiation-Injured Rat Bowel. Gynecologic Oncology, 70(1), 121–122. doi:10.1006/gyno.1998.5045
31- Karahasanoglu, Altinli, Hamzaoglu, Paksoy, Yesildere, Alemdaroglu. (1998). Effect of growth hormone treatment on the healing of left colonic anastomoses in protein-malnourished rats. British Journal of Surgery, 85(7), 931–933.doi:10.1046/j.1365-2168.1998.00696.x
32- Ceran C., Aksoy R. T., Gülbahar Ö., Öztürk F. The effects of ghrelin on colonic anastomosis healing in rats. (2013) Clinics [Internet]. Available from: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S180759322013000200019&lng=en. http://dx.doi.org/10.6061/CLINICS/2013(02)OA19.
33- Teke Z., Bostanci E. B., Yenisey C., Kelten E. C., Sacar M., Simsek N. G., Akoglu, M. (2012). Caffeic Acid Phenethyl Ester Prevents Detrimental Effects of Remote Ischemia-Reperfusion Injury on Healing of Colonic Anastomoses. Journal of Investigative Surgery, 26(1), 16–29.doi:10.3109/08941939.2012.687434
34- Turku O, et al. The effect of erythropoietin on anastomotic healing of irradiated rats. (2012) J invest Surg.
35- Pavlidis, E. T., Ballas, K. D., Symeonidis, N. G., Psarras, K., Koliakos, G., Kouzi-Koliakos, K. Sakantamis, A. K. (2010). The effect of bevacizumab on colon anastomotic healing in rats. International Journal of Colorectal Disease, 25(12), 1465–1473.doi:10.1007/s00384-010-1039-x
36- Yalçın, A. S. (2006) Emerging therapeutic potential of whey proteins and peptides. Curr. Pharm. Des. 12, 1637–1643.
37- Velioglu Ogunç, et al. (2008) Dietary whey supplementation in experimental models of wound healing. International journal of vitamin and nutrition research, 78(2), 70-73.
38- Temiz, M., Aslan, A., Canbolant, E., Hakverdi, S., Polat, G., Uzun, S., Gonenci, R. (2008). Effect of propolis on healing in experimental colon anastomosis in rats. Advances in Therapy, 25(2), 159–167.doi:10.1007/s12325-008-0013-2
Published
2019-12-31
How to Cite
CARNEIRO, Andrey de Almeida et al.
Use of Antioxidant Substances in Intestinal Anastomosis in Rats.
International Archives of Medicine, [S.l.], v. 12, dec. 2019.
ISSN 1755-7682.
Available at: <http://imedicalpublisher.com/ojs/index.php/iam/article/view/2912>. Date accessed: 01 june 2023.
doi: https://doi.org/10.3823/2616.
Issue
Section
General Surgery
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